I am a Stem Cell Scientist leading the research group for modelling cerebrovascular diseases using patient-derived induced pluripotent stem cells (iPSC).
I obtained my PhD in Cell and Developmental Biology at King’s College London and completed two postdoctoral research fellowships in the department of Clinical Neurosciences at UCL and in the department of Medicine, Cardiovascular Division, at the University of Cambridge.
Currently I am working on a project to develop human iPSC-based models to investigate the mechanisms underlying genetic Cerebral Small Vessel Diseases. I believe that iPSC model offer a powerful screening platform for new target/drug discovery and personalised medicine, ultimately, resulting in improved patient care.
Granata, A. et al. An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Nat. Genet. (2016). doi:10.1038/ng.3723
Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Granata A, Bernard WG, Zhao N, Mccafferty J, Lilly B, Sinha S. Stem Cells Dev. 2015 Apr 1;24(7):846-56.
Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application. Sinha S, Iyer D, Granata A. Cell Mol Life Sci. 2014 Jun;71(12):2271-88.