The laboratories of Professor Roger Barker/Caroline Williams-Gray and Professor James B. Rowe work together to determine and better understand the mechanisms underlying neurodegenerative disease and dementia. They discover how diseases such as dementia, Parkinson’s disease and Huntington’s disease affect critical neural networks, cognitive systems and clinical features. Their innovative approach to “Systems and Restorative Neurology (SyReN)” is used to develop new treatments, translating basic science to novel therapies, and evaluating the impact on symptoms and the course of disease.
We work in close partnership with patients and carers, combining specialist services for NHS patients with internationally recognized research programs into the causes, mechanisms and treatments of disease. Examples of our work include:
Dementia and Ageing:
- The PiPPIN (Pick’s disease and Progressive Supranuclear Palsy, Prevalence and INcidence) study of FTD
- Action control and learning at the Cambridge Centre for Ageing and Neuroscience (see Cam-CAN)
- Decision making and dementia
- Genetic Frontotemporal Dementia Initiative (GENFI)
- PRePAReD: Prospective Evaluation of Parkinson’s Plus and Related Disorders
- NIMROD study of neuroinflammation in Dementia (see also the NIHR Clinical Research Network Portfolio)
- Understanding Cognition and Action in FTD
- MRC “Deep and Frequent Phenotyping” and membership of the UK Dementia Platform
- PROSPECT-M-UK on Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal syndrome (CBS)
- Parkinson’s Plus Disorders (CCPP)
- Clinical trial NORAPS
- CUMIN C study
The Cambridge Centre for Frontotemporal Dementia and Related Disorders
- The CCFTD provides world class care for patients and families combined with cutting edge research towards better diagnosis and effective treatments.
Parkinson’s disease:
- Cohort studies CamPaIGN/PICNICS/ICICLE-PD/Tracking Parkinsons (PRoBaND)
- Clinical trials TRANSNEURO/AZA-PD/OXB-102
- Research projects in PD
Huntington’s disease:
- Cohort studies ENROL-HD
- Clinical trials IONIS/EIP
- Research projects in HD