About me

I am a Research Associate studying the role of cerebrovascular dysfunction in dementia and cognitive impairment, with the help of multimodal neuroimaging techniques and clinical data in humans.

Currently, my research focuses on the associations between cerebral small vessel disease, inflammation, and blood brain barrier permeability. I am also interested in studying the early risk factors of dementia, and how cerebral small vessel disease is involved in early dementia pathogenesis. In particular, I am interested in how cerebral small vessel disease relates to established dementia risk factors and molecular imaging markers of dementia (e.g., amyloid, tau, neuroinflammation), as a way to further our understanding of how various pathologies interact in their contribution to neurodegeneration and clinical outcomes.

 

Selected publications

2022

• Low A, Prats-Sedano M, McKiernan E, Carter S, Stefaniak JD, Nannoni S, Su L, Dounavi ME, Muniz-Terrera G, Ritchie K, Lawlor B, Naci L, Malhotra P, MacKay C, Koychev I, Ritchie CW, Markus HS, O’Brien JT. Modifiable and non-modifiable risk factors of dementia and midlife cerebral small vessel disease in cognitively healthy midlife adults: the PREVENT-Dementia study. Alz Res Therapy. 2022; 14: 154. doi:10.1186/s13195-022-01095-4.
• Low A, Prats-Sedano, MA, Stupart O, Stefaniak JD, McKiernan E, Carter S, Dounavi ME, Mak E, Su L, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O’Brien JT. CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study. J Neurol Neurosurg Psychiatry. 2022; 93:481-490. doi:10.1136/jnnp-2021-327462.

2021

• Low A, Su L, Stefaniak JD, Mak E, Dounavi ME, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O’Brien JT. Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study. Neurobiol Aging. 2021; 98:124-133. doi:10.1016/j.neurobiolaging.2020.10.029.
• Brown R, Low A, Markus HS. Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design. J Neurol Neurosurg Psychiatry. 2021; 92(12):1271-1277. doi:10.1136/jnnp-2021-326569.

2020

• Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB, Markus HS, O’Brien JT. In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2020; 11; 92(1): 45-52. doi:10.1136/jnnp-2020-323894.
• Low A, Mak E, Rowe JB, Markus HS, O’Brien JT. Inflammation and cerebral small vessel disease: A systematic review. Ageing Res Rev. 2020; 53:100916. doi:10.1016/j.arr.2019.100916.

A comprehensive list of publications is available on the following sites:

• Academic website: https://audreylwn.github.io/
• Google Scholar: https://scholar.google.com/citations?user=Ka8dILwAAAAJ
• ORCID: https://orcid.org/0000-0002-2520-454X