I am a PhD student in the Department of Clinical Neurosciences, supervised by Professor Hugh Markus. I previously completed my undergraduate degree at Bristol University, during which I spent a year on placement within the imaging team at GlaxoSmithKline.
My PhD project will investigate the role of blood brain barrier (BBB) permeability in the pathology of cerebral small vessel disease (SVD). We will be using magnetic resonance imaging (MRI) techniques to both quantify and map BBB leakage with damage to brain regions in individual patients. We will also determine whether increased BBB permeability correlates with both clinical parameters and serum markers of endothelial activation and BBB disruption. We are interested in how common BBB breakdown is, where it occurs, its relationship to other MRI disease markers and whether it can predict which brain regions will go on to develop permanent damage.
This work is supported by the British Heart Foundation Cambridge Centre of Excellence.