Dementia and Neurodegeneration Research Projects
Applying Systems and Restorative Neurology (SyReN)
On Parkinson’s disease:
- The PICNICS and ICICLE-PD studies of Parkinson’s disease
- The Prosavin Gene therapy trial in Parkinson’s disease
- TransEURO stem cell transplantation trial
- Understanding Cognition and Action in Parkinson’s disease
On Dementia and Ageing:
- The PIPPIN (Pick’s disease and Progressive Supranuclear Palsy, Prevalence and INcidence) study of Frontotemporal dementia
- Action control and learning at the Cambridge Centre for Ageing and Neuroscience (see Cam-CAN)
- Decision making and dementia
- Genetic Frontotemporal Dementia Initiative (GENFI)
- Diagnosis and prognosis in PSP, CBD, and FTD
- NIMROD study of neuroinflammation in Dementia (see also the UK Clinical Research Network Portfolio)
- Understanding Cognition and Action in Pick’s disease
- MRC “Deep and Frequent Phenotyping” and membership of the UK Dementia Platform
- PROSPECT-M-UK on Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal syndrome (CBS)
On Huntington’s disease:
- The Enroll-HD prospective registry study in Huntington’s disease
- The PREDICT-HD study looking for the earliest detectable changes in premanifest Huntington’s disease
In many of these studies we bring a multimodal approach, using neuroimaging techniques (functional Magnetic Resonance Imaging MRI, Positron emission tomography PET and Magnetoencephalography MEG), pharmacological treatments in combination with psychology and imaging, and computer modelling of behaviour and brain data in addition to epidemiology and genetics. For patients, this ensures patient-focussed high impact research. For junior doctors and researchers, it ensures a world class training in the UK’s leading environment for Neuroscience and Mental Health research and a dynamic but friendly department.
Funding: Systems and Restorative Neurology is supported by the Wellcome Trust, The Medical Research Council, the NIHR Biomedical Research Centre and Biomedical Research Unit for Dementia, Alzheimer’s Research UK, Parkinson’s UK, the PSP Association, The Evelyn Trust, The Newton Trust, the James S. McDonnell Foundation, the Dunhill Trust and the generous support of many individual donors and fundraisers.